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Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities

Received: 11 October 2018     Accepted: 29 October 2018     Published: 21 November 2018
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Abstract

The purpose of this study was to evaluate the antioxidant activity of compounds isolated from Clerodendrum splendens leaves. The leaves of Clerodendrum splendens are used in traditional medicine by indegenous people to treat shingles, spleen in children, asthma, rheumatism, ulcers and malaria. In vivo and in vitro studies carried out by many researchers have shown that Clerodendrum splendens has antioxidant properties. The chemical study of the methanol extract of Clerodendrum splendens leaves (Lamiaceae) led to the isolation of three compounds: Triancontanol (1), (22E, 24S) - Stigmasta - 5, 22, 25 - trien – 3β-ol(2); 3-O-D-glucopyranoside of (22E, 24S) - Stigmasta - 5,22,25 - trien - 3β-ol (3). Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. The results of the antioxidant activity have shown that the compounds 1 and 2 inhibit the peroxidation of the hepatic lipids, they also show that the compounds 1, 2 and 3 have a reducing effect on Fe2+. However, the compounds 1, 2 and 3 have an OH reduction power which is directly proportional to the concentration of these compounds compared to that of vitamin C, which made it possible to determine the IC50 of the different compounds. Furthermore, the compounds 1 and 2 have higher IC50 than that of vitamin C (5.613 ± 0.117). The results of this study suggest that Clerodendrum splendens represents an untapped source of compounds with potential antioxidant activity that could be explored in the development of new therapeutic natural products.

Published in Journal of Diseases and Medicinal Plants (Volume 4, Issue 5)
DOI 10.11648/j.jdmp.20180405.11
Page(s) 120-127
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Clerodendrum splendens, Lamiaceae, Antioxidant Activities, Secondary Metabolites

References
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Cite This Article
  • APA Style

    Nganso Ditchou Yves Oscar, Tatsimo Ndendoung Simplice Joel, Amang A. Ngoung Gabrielle Ange, Soh Desire, Simo Nemg Fredy Brice, et al. (2018). Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities. Journal of Diseases and Medicinal Plants, 4(5), 120-127. https://doi.org/10.11648/j.jdmp.20180405.11

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    ACS Style

    Nganso Ditchou Yves Oscar; Tatsimo Ndendoung Simplice Joel; Amang A. Ngoung Gabrielle Ange; Soh Desire; Simo Nemg Fredy Brice, et al. Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities. J. Dis. Med. Plants 2018, 4(5), 120-127. doi: 10.11648/j.jdmp.20180405.11

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    AMA Style

    Nganso Ditchou Yves Oscar, Tatsimo Ndendoung Simplice Joel, Amang A. Ngoung Gabrielle Ange, Soh Desire, Simo Nemg Fredy Brice, et al. Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities. J Dis Med Plants. 2018;4(5):120-127. doi: 10.11648/j.jdmp.20180405.11

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  • @article{10.11648/j.jdmp.20180405.11,
      author = {Nganso Ditchou Yves Oscar and Tatsimo Ndendoung Simplice Joel and Amang A. Ngoung Gabrielle Ange and Soh Desire and Simo Nemg Fredy Brice and Nyasse Barthelemy},
      title = {Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities},
      journal = {Journal of Diseases and Medicinal Plants},
      volume = {4},
      number = {5},
      pages = {120-127},
      doi = {10.11648/j.jdmp.20180405.11},
      url = {https://doi.org/10.11648/j.jdmp.20180405.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20180405.11},
      abstract = {The purpose of this study was to evaluate the antioxidant activity of compounds isolated from Clerodendrum splendens leaves. The leaves of Clerodendrum splendens are used in traditional medicine by indegenous people to treat shingles, spleen in children, asthma, rheumatism, ulcers and malaria. In vivo and in vitro studies carried out by many researchers have shown that Clerodendrum splendens has antioxidant properties. The chemical study of the methanol extract of Clerodendrum splendens leaves (Lamiaceae) led to the isolation of three compounds: Triancontanol (1), (22E, 24S) - Stigmasta - 5, 22, 25 - trien – 3β-ol(2); 3-O-D-glucopyranoside of (22E, 24S) - Stigmasta - 5,22,25 - trien - 3β-ol (3). Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. The results of the antioxidant activity have shown that the compounds 1 and 2 inhibit the peroxidation of the hepatic lipids, they also show that the compounds 1, 2 and 3 have a reducing effect on Fe2+. However, the compounds 1, 2 and 3 have an OH reduction power which is directly proportional to the concentration of these compounds compared to that of vitamin C, which made it possible to determine the IC50 of the different compounds. Furthermore, the compounds 1 and 2 have higher IC50 than that of vitamin C (5.613 ± 0.117). The results of this study suggest that Clerodendrum splendens represents an untapped source of compounds with potential antioxidant activity that could be explored in the development of new therapeutic natural products.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities
    AU  - Nganso Ditchou Yves Oscar
    AU  - Tatsimo Ndendoung Simplice Joel
    AU  - Amang A. Ngoung Gabrielle Ange
    AU  - Soh Desire
    AU  - Simo Nemg Fredy Brice
    AU  - Nyasse Barthelemy
    Y1  - 2018/11/21
    PY  - 2018
    N1  - https://doi.org/10.11648/j.jdmp.20180405.11
    DO  - 10.11648/j.jdmp.20180405.11
    T2  - Journal of Diseases and Medicinal Plants
    JF  - Journal of Diseases and Medicinal Plants
    JO  - Journal of Diseases and Medicinal Plants
    SP  - 120
    EP  - 127
    PB  - Science Publishing Group
    SN  - 2469-8210
    UR  - https://doi.org/10.11648/j.jdmp.20180405.11
    AB  - The purpose of this study was to evaluate the antioxidant activity of compounds isolated from Clerodendrum splendens leaves. The leaves of Clerodendrum splendens are used in traditional medicine by indegenous people to treat shingles, spleen in children, asthma, rheumatism, ulcers and malaria. In vivo and in vitro studies carried out by many researchers have shown that Clerodendrum splendens has antioxidant properties. The chemical study of the methanol extract of Clerodendrum splendens leaves (Lamiaceae) led to the isolation of three compounds: Triancontanol (1), (22E, 24S) - Stigmasta - 5, 22, 25 - trien – 3β-ol(2); 3-O-D-glucopyranoside of (22E, 24S) - Stigmasta - 5,22,25 - trien - 3β-ol (3). Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. The results of the antioxidant activity have shown that the compounds 1 and 2 inhibit the peroxidation of the hepatic lipids, they also show that the compounds 1, 2 and 3 have a reducing effect on Fe2+. However, the compounds 1, 2 and 3 have an OH reduction power which is directly proportional to the concentration of these compounds compared to that of vitamin C, which made it possible to determine the IC50 of the different compounds. Furthermore, the compounds 1 and 2 have higher IC50 than that of vitamin C (5.613 ± 0.117). The results of this study suggest that Clerodendrum splendens represents an untapped source of compounds with potential antioxidant activity that could be explored in the development of new therapeutic natural products.
    VL  - 4
    IS  - 5
    ER  - 

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Author Information
  • Department of Chemistry, Faculty of Science, University of Maroua, Maroua, Cameroon

  • Department of Chemistry, Higher Teachers’ Training College, University of Maroua, Maroua, Cameroon

  • Department of Chemistry, Faculty of Science, University of Maroua, Maroua, Cameroon

  • Department of Organic Chemistry, Higher Teachers’ Training College, University of Bamenda, Bamenda, Cameroon

  • Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon

  • Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon

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